001. RAC1 as a potential pan-cancer diagnostic, prognostic, and immunological biomarker
Transl Cancer Res. 2024 PMID:38617518 |
|
002. Alnustone promotes megakaryocyte differentiation and platelet production via the interleukin-17A/interleukin-17A receptor/Src/RAC1/MEK/ERK signaling pathway
Eur J Pharmacol. 2024 PMID:38570080 |
|
003. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury
Nat Commun. 2024 PMID:38286811 |
|
004. Assessment of TUFT1 and Rac1-GTP levels in triple-negative breast cancer patients: clinical and pathological correlations
Clin Transl Oncol. 2024 PMID:38478261 |
|
005. Inhibition of spinal Rac1 attenuates chronic inflammatory pain by regulating the activation of astrocytes
Cell Signal. 2024 PMID:37984604 |
|
006. Reduction of Doxorubicin-Induced Cardiotoxicity by Co-Administration of Smart Liposomal Doxorubicin and Free Quercetin: In Vitro and In Vivo Studies
Pharmaceutics. 2023 PMID:37514106 |
|
007. The activated CD36-Src axis promotes lung adenocarcinoma cell proliferation and actin remodeling-involved metastasis in high-fat environment
Cell Death Dis. 2023 PMID:37612265 |
|
008. HSC70 mediated autophagic degradation of oxidized PRL2 is responsible for osteoclastogenesis and inflammatory bone destruction
Cell Death Differ. 2023 PMID:36182990 |
|
009. CD36 initiates Src signal transduction to promote actin remodeling-involved metastasis of lung adenocarcinoma in high-fat environment
Research Square,. 2023 PMID: |
|
010. Downregulation of CYRI-B promotes migration, invasion and EMT by activating the Rac1-STAT3 pathway in gastric cancer
Exp Cell Res. 2023 PMID:36584745 |
|
011. Glucuronoxylomannan intranasal challenge prior to Cryptococcus neoformans pulmonary infection enhances cerebral cryptococcosis in rodents
PLoS Pathog. 2023 PMID:37115795 |
|
012. Tumoricidal Activity of Simvastatin in Synergy with RhoA Inactivation in Antimigration of Clear Cell Renal Cell Carcinoma Cells
Int J Mol Sci. 2023 PMID:37298689 |
|
013. Loss of cell-cell adhesion triggers cell migration through Rac1-dependent ROS generation
Life Sci Alliance. 2022 PMID:36446524 |
|
014. The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration
Life Sci Alliance. 2022 PMID:36598812 |
|
015. Rac1 and Rac3 GTPases and TPC2 are required for axonal outgrowth and migration of cortical interneurons
J Cell Sci. 2023 PMID:36744839 |
|
016. The Scaffold RhoGAP Protein ARHGAP8/ BPGAP1 Synchronizes Rac and Rho Signaling to Facilitate Cell Migration
Mol Biol Cell. 2023 PMID:36598812 |
|
017. Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles
J Cell Commun Signal. 2022 PMID:36508052 |
|
018. Loss of cell–cell adhesion triggers cell migration through Rac1-dependent ROS generation
Life Sci Alliance. 2022 PMID:36446524 |
|
019. Catalpol inhibits hepatic stellate cell activation by reducing the formation and changing the contents of hepatocyte-derived extracellular vesicles
J Cell Commun Signal. 2022 PMID:36508052 |
|
020. Cardiac inducing colonies halt fibroblast activation and induce cardiac/endothelial cells to move and expand via paracrine signaling
Mol Biol Cell. 2022 PMID:35653297 |
|
021. Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice
Cell Death Discov. 2022 PMID:35031595 |
|
022. Smooth muscle Rac1 contributes to pulmonary hypertension
BJP. 2022 PMID:35064565 |
|
023. Rac1 mediates cadherin-11 induced cellular pathogenic processes in aortic valve calcification
Cardiovasc Pathol. 2022 PMID:35074515 |
|
024. A Portable Controllable Compressive Stress Device to Monitor Human Breast Cancer Cell Protrusions at Single-Cell Resolution
J Clin Invest. 2022 PMID:35104805 |
|
025. Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition – More Than Just ROS-inhibition
J Clin Transl Hepatol. 2022 PMID:35233372 |
|
026. Targeting the ASMase/S1P pathway protects from sortilin-evoked vascular damage in hypertension
J Neuroinflammation. 2022 PMID:35284404 |
|
027. Planar cell polarity-dependent asymmetric organization of microtubules for polarized positioning of the basal body in node cells
Development. 2022 PMID:35420656 |
|
028. Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in Rats
Front Mol Neurosci. 2022 PMID:35782392 |
|
029. Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor
Front Bioeng Biotechnol. 2022 PMID:35831873 |
|
030. ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42
J Exp Clin Cancer Res. 2022 PMID:35869555 |
|
031. Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery
Sci Adv. 2022 PMID: 36129975 |
|
032. Differential dysregulation of granule subsets in WASH-deficient neutrophil leukocytes resulting in inflammation
Nat Commun. 2022 PMID: 36130971 |
|
033. The Pro-Fibrotic Response to Lens Injury Is Signaled in a PI3K Isoform-Specific Manner
Biomolecules. 2022 PMID:36139020 |
|
034. Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage
Cell Death Dis. 2022 PMID:36229446 |
|
035. Critical role of mitogen-inducible gene 6 in restraining endothelial cell permeability to maintain vascular homeostasis
J Cell Commun Signal. 2022 PMID:36284029 |
|
036. PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate
Biomolecules. 2022 PMID:36291720 |
|
037. Dock4 is required for the maintenance of cochlear hair cells and hearing function
Fundamental Research. 2022 |
038. The GABAB receptor mediates neuroprotection by coupling to G13
Sci Signal. 2021 PMID:34665640 |
|
039. 22-O-(N-Boc-L-glycine) ester of renieramycin M inhibits migratory activity and suppresses epithelial-mesenchymal transition in human lung cancer cells
J Nat Med. 2021 PMID:34287745 |
|
040. A role of PIEZO1 in iron metabolism in mice and humans.
Cell. 2021 PMID:33571427 |
|
041. A RAC-GEF network critical for early intestinal tumourigenesis
Nat Commun. 2021 PMID:33397922 |
|
042. Arhgef6 (alpha-PIX) cytoskeletal regulator signals to GTPases and Cofilin to couple T cell migration speed and persistence
J Leukoc Biol. 2021 PMID:33527537 |
|
043. Essential role of smooth muscle Rac1 in severe asthma-associated airway remodelling
Thorax. 2021 PMID:33542087 |
|
044. 7-ketocholesterol induces endothelial-mesenchymal transition and promotes fibrosis: implications in neovascular age-related macular degeneration and treatment
Angiogenesis. 2021 PMID:33646466 |
|
045. Dihydroceramide desaturase regulates the compartmentalization of Rac1 for neuronal oxidative stress
Cell Rep. 2021 PMID:33852856 |
|
046. Apoptotic cells in mouse blastocysts are eliminated by neighbouring blastomeres
Sci Rep. 2021 PMID:33927296 |
|
047. EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice
eLife. 2021 PMID:33973520 |
|
048. MFG‐E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose‐Dependent Mediation of Actin Polymerization
J Am Heart Assoc. 2021 PMID:34041925 |
|
049. Hydrostatic mechanical stress regulates growth and maturation of the atrioventricular valve
Development. 2021 PMID:34086041 |
|
050. Flexible Ultrasonic Patch for Accelerating Chronic Wound Healing
Adv Healthc Mater. 2021 PMID:34212532 |
|
051. Deregulated Rac1 Activity in Neural Crest Controls Cell Proliferation, Migration and Differentiation During Midbrain Development
Front Cell Dev Biol. 2021 PMID:34557485 |
|
052. Decoupling Tumor Cell Metastasis From Growth By Cellular Pilot Protein TNFAIP8
Oncogene. 2021 PMID:34608264 |
|
053. Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells
Exp Cell Res. 2021 PMID:34626585 |
|
054. Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw
Front Cell Dev Biol. 2021 PMID:34805177 |
|
055. Collective durotaxis along a self-generated stiffness gradient in vivo
Nature. 2021 PMID:34880503 |
|
056. Sustained Release of Gas6 via mPEG-PLGA Nanoparticles Enhances the Therapeutic Effects of MERTK Gene Therapy in RCS Rats
Front Med (Lausanne). 2021 PMID:34970569 |
|
057. yk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages
Front Immunol. 2021 PMID:35003083 |
|
058. Voltage‐dependent activation of Rac1 by Nav1.5 channels promotes cell migration
J Cell Physiol. 2020 PMID:31612502 |
|
059. Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis
Neurobiol Dis. 2020 PMID:31931138 |
|
060. Statins Disrupt Macrophage Rac1 Regulation Leading to Increased Atherosclerotic Plaque Calcification
Arterioscler Thromb Vasc Biol. 2020 PMID:31996022 |
|
061. Spaced Training Enhances Contextual Fear Memory via Activating Hippocampal 5-HT2A Receptors
Front Mol Neurosci. 2020 PMID:32038159 |
|
062. Glycolysis Independent Glucose Metabolism Distinguishes TE from ICM Fate During Mammalian Embryogenesis
Dev Cell. 2020 PMID:32197068 |
|
063. Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation
Nat Commun. 2020 PMID:32246016 |
|
064. The TIPE Molecular Pilot That Directs Lymphocyte Migration in Health and Inflammation
Sci Rep. 2020 PMID:32313148 |
|
065. Rac1 activation in human breast carcinoma as a prognostic factor associated with therapeutic resistance
Breast Cancer. 2020 PMID:32314182 |
|
066. Rac1-dependent phagocytosis of apoptotic cells by oral squamous cell carcinoma cells: A possible driving force for tumor progression
Experimental Cell Research. 2020 PMID:32320683 |
|
067. PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation
Int J Mol Sci. 2020 PMID:32580367 |
|
068. The laminin-211-derived PPFEGCIWN motif accelerates wound reepithelialization and increases phospho-FAK-Tyr397 and Rac1-GTP levels in a rat excisional wound splinting model
J Tissue Eng Regen Med. 2020 PMID: 32592615 |
|
069. Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration
eLife. 2020 PMID:32705984 |
|
070. TIQGAP1 Causes Choroidal Neovascularization by Sustaining VEGFR2-mediated Rac1 Activation
Angiogenesis. 2020 PMID:32783108 |
|
071. Mitofusin 2 regulates neutrophil adhesive migration and the actin cytoskeleton
J Cell Sci. 2020 PMID:32788232 |
|
072. Oxygen sensor FIH inhibits HACE1-dependent ubiquitination of Rac1 to enhance metastatic potential in breast cancer cells
Oncogene. 2019 PMID:30659265 |
|
073. The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration
J Leukoc Biol. 2019 PMID:30748033 |
|
074. Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82
Bone Reports. 2019 PMID:30788390 |
|
075. Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis
Gynecol Oncol. 2019 PMID:30797592 |
|
076. Epigenetic Regulation of the PTEN-AKT-RAC1 Axis by G9a Is Critical for Tumor Growth in Alveolar Rhabdomyosarcoma
Cancer Res. 2019 PMID:30833420 |
|
077. In vivo topology converts competition for cell-matrix adhesion into directional migration
Nat Commun. 2019 PMID:30944331 |
|
078. Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling
Int J Mol Sci. 2019 PMID:30866434 |
|
079. Cdc42 activation by endothelin regulates neural crest cell migration in the cardiac outflow tract
Dev Dyn. 2019 PMID: 31219639 |
|
080. TUFT1 Promotes Triple Negative Breast Cancer Metastasis. Stemness. and Chemoresistance by Up-Regulating the Rac1/β-Catenin Pathway
Front Oncol. 2019 PMID:31338333 |
|
081. Simvastatin pretreatment ameliorates t-PA–induced hemorrhage transformation and MMP-9/TIMP-1 imbalance in thromboembolic cerebral ischemic rats
Neuropsychiatr Dis Treat. 2019 PMID:31410004 |
|
082. PTPσ inhibitors promote hematopoietic stem cell regeneration
Nature Communications. 2019 PMID:31413255 |
|
083. Quercetin Mitigates Hepatic Insulin Resistance in Rats with Bile Duct Ligation Through Modulation of the STAT3/SOCS3/IRS1 Signaling Pathway
J Food Sci. 2019 PMID:31529802 |
|
084. TUFT1 promotes metastasis and chemoresistance in triple negative breast cancer through the TUFT1ab5ac1 pathway
Cancer Cell Int. 2019 PMID:31572059 |
|
085. Chemokine Receptor CCR7 Triggers an Endomembrane Signaling Complex for Spatial Rac Activation
Cell Rep. 2019 PMID:31644919 |
|
086. Interplay between …2-chimaerin and Rac1 activity determines dynamic maintenance of long-term memory
Nat Commun. 2019 PMID:31757963 |
|
087. Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness
J Allergy Clin Immunol. 2018 PMID:29155102 |
|
088. COL1A1 promotes metastasis in colorectal cancer by regulating the WNT/PCP pathway
Mol Med Rep. 2018 PMID:29393423 |
|
089. Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart
Cardiovasc Res. 2018 PMID:29444209 |
|
090. p66Shc Regulates Migration of Castration-Resistant Prostate Cancer Cells
Cell Signal. 2018 PMID:29462661 |
|
091. Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice
Cell Death Dis. 2018 PMID:29497040 |
|
092. Protein tyrosine kinase 7 regulates extracellular matrix integrity and mesenchymal intracellular RAC1 and myosin II activities during Wolffian duct morphogenesis
Dev Biol. 2018 PMID:29580943 |
|
093. Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth
Cancer Discov. 2018 PMID:29581176 |
|
094. Complement C3 Affects Rac1 Activity in the Developing Brain
Front Mol Neurosci. 2018 PMID:29867343 |
|
095. The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8 + T cells
J Exp Med. 2018 PMID:29875261 |
|
096. RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3
Laboratory Investigation. 2018 PMID:29884911 |
|
097. Removing physiological motion from intravital and clinical functional imaging data
eLife. 2018 PMID:29985127 |
|
098. Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer’s disease
Acta Neuropathol Commun. 2018 PMID:30005699 |
|
099. MicroRNA-650 targets inhibitor of growth 4 to promote colorectal cancer progression via mitogen activated protein kinase signaling
Oncol Lett. 2018 PMID:30008936 |
|
100. The tetraspanin CD82 regulates bone marrow homing and engraftment of hematopoietic stem and progenitor cells
Mol Biol Cell. 2018 PMID:30133344 |
|
101. The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion
Oncogene. 2017 PMID:27669437 |
|
102. Massively Increased Caries Susceptibility in an Irf6 Cleft Lip/Palate Model
J Dent Res. 2017 PMID:27927890 |
|
103. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary
PLoS Genet. 2017 PMID:28072828 |
|
104. Biological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma
Oncotarget. 2017 PMID:28423558 |
|
105. Rac1 activation in podocytes induces the spectrum of nephrotic syndrome
Kidney Int. 2017 PMID:28483380 |
|
106. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis
Dev Biol. 2017 PMID:28552735 |
|
107. High glucose levels promote the proliferation of breast cancer cells through GTPases
Breast Cancer (Dove Med Press). 2017 PMID:28670141 |
|
108. Role of Nicotinamide N-Methyltransferase in Dorsal Striatum in Cocaine Place Preference
Neuropsychopharmacology. 2017 PMID:28726800 |
|
109. The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage
Blood. 2017 PMID:28743719 |
|
110. Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function
Hum Mol Genet. 2017 PMID:29016860 |
|
111. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2
Nature Immunology. 2017 PMID:29058702 |
|
112. A PTEN-COL17A1 fusion gene and its novel regulatory role in Collagen XVII expression and GBM malignance
Oncotarget. 2017 PMID:29156757 |
|
113. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery
eLife. 2017 PMID:29271742 |
|
114. Disease-causing mutations of RhoGDIa induce Rac1 hyperactivation in podocytes
Small GTPases. 2016 PMID:26726844 |
|
115. The acetylenic tricyclic bis(cyano enone). TBE-31. targets microtubule dynamics and cell polarity in migrating cells
Biochim Biophys Acta. 2016 PMID:26775215 |
|
116. Dosage-dependent role of Rac1 in podocyte injury
Am J Physiol Renal Physiol. 2016 PMID:26792065 |
|
117. Rac1/β-Catenin Signalling Pathway Contributes to Trophoblast Cell Invasion by Targeting Snail and MMP9.
Cell Physiol Biochem. 2016 PMID:27008403 |
|
118. A Stromal Cell–Derived Factor 1a Analogue Improves Endothelial Cell Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome
Mol Med. 2016 PMID:27031787 |
|
119. The RacGAP protein FilGAP is a negative regulator of chemokine-promoted lymphocyte migration
FEBS Lett. 2016 PMID: 27130700 |
|
120. Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice
Eur J Immunol. 2016 PMID: 27188212 |
|
121. Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear.
Neuropharmacology. 2016 PMID:27329554 |
|
122. Zinc induces epithelial to mesenchymal transition in human lung cancer H460 cells via superoxide anion-dependent mechanism
Cancer Cell Int. 2016 PMID:27330411 |
|
123. RAC-LATS1/2 signaling regulates YAP activity by switching between the YAP-binding partners TEAD4 and RUNX3
Oncogene. 2016 PMID:27425596 |
|
124. Dietary flavonoid luteolin attenuates uropathogenic Escherichia. Coli invasion of the urinary bladder.
Biofactors. 2016 PMID:27452812 |
|
125. Sur8 mediates tumorigenesis and metastasis in colorectal cancer
Exp Mol Med. 2016 PMID:27469030 |
|
126. The modulation of MiR-155 and MiR-23a manipulates Klebsiella pneumoniae Adhesion on Human pulmonary Epithelial cells via Integrin α5β1 Signaling
Sci Rep. 2016 PMID:27534887 |
|
127. Gigantol Inhibits Epithelial to Mesenchymal Process in Human Lung Cancer Cells
Evid Based Complement Alternat Med. 2016 PMID:27651818 |
|
128. Rac1 modulates mammalian lung branching morphogenesis in part through canonical Wnt signaling
Am J Physiol Lung Cell Mol Physiol. 2016 PMID:27765763 |
|
129. Converging. Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses
J Neurosci. 2016 PMID:27807170 |
|
130. Rac signal adaptation controls neutrophil mobilization from the bone marrow
Sci Signal. 2016 PMID:27999173 |
|
131. miRNA-17 members that target Bmpr2 influence signaling mechanisms important for embryonic stem cell differentiation in vitro and gastrulation in embryos
Stem Cells Dev. 2015 PMID:25209090 |
|
132. LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix
Cancer Lett. 2015 PMID:25451317 |
|
133. Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1
Cancer letters. 2015 PMID:25529012 |
|
134. Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer
Clin Cancer Res. 2015 PMID:25595279 |
|
135. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory
Mol Neurobiol. 2015 PMID:25613020 |
|
136. Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase
J Biol Chem. 2015 PMID:25666619 |
|
137. Fibroblastic Transformation of Corneal Keratocytes by Rac Inhibition is Modulated by Extracellular Matrix Structure and Stiffness
J Funct Biomater. 2015 PMID:25874856 |
|
138. Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation. reactive oxygen species production. and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway
BMC Complement Altern Med. 2015 PMID:25886843 |
|
139. TIPE2 protein prevents injury-induced restenosis in mice
Biochim Biophys Acta. 2015 PMID:25912734 |
|
140. Dishevelled-2 regulates cocaine-induced structural plasticity and Rac1 activity in the nucleus accumbens
Neurosci Lett. 2015 PMID:25957559 |
|
141. A bibenzyl from Dendrobium ellipsophyllum inhibits migration in lung cancer cells
J Nat Med. 2015 PMID:26109451 |
|
142. The cytohesin guanosine exchange factors (GEFs) are required to promote HGF-mediated renal recovery after acute kidney injury (AKI) in mice
Physiol Rep. 2015 PMID:26116550 |
|
143. A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration
Nat Commun. 2015 PMID:26166433 |
|
144. Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice
Cell Death Differ. 2015 PMID:26184908 |
|
145. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
Nat Commun. 2015 PMID:26234763 |
|
146. Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2
Neuroscience. 2015. PMID:26299339 |
|
147. Rac1 Regulates Endometrial Secretory Function to Control Placental Development
PLoS Genet. 2015 PMID:26305333 |
|
148. Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling
Oncotarget. 2015 PMID:26384305 |
|
149. Rac1 augments Wnt signaling by stimulating beta-catenin-LEF-1 complex assembly independent of beta-catenin nuclear import
J Cell Sci. 2015 PMID:26403202 |
|
150. Rap1 GTPase Inhibits Tumor Necrosis Factor-à-Induced Choroidal Endothelial Migration via NADPH Oxidase- and NF-?B-Dependent Activation of Rac1
Am J Pathol. 2015 PMID:26476350 |
|
151. Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve
Current Biology. 2015 PMID:26725196 |
|
152. Immunofluorescence and Confocal Microscopy of Neutrophils
Methods Mol Biol. 2014 PMID:18453118 |
|
153. Jak3 Enables Chemokine-Dependent Actin Cytoskeleton Reorganization by Regulating Cofilin and Rac/Rhoa GTPases activation
PLoS One. 2014 PMID:24498424 |
|
154. High incidence of naevi-associated BRAF wild-type melanoma and dysplastic naevi under treatment with the class I BRAF inhibitor vemurafenib
Acta Derm Venereol. 2014 PMID:24531394 |
|
155. A link between the nuclear-localized srGAP3 and the SWI/SNF chromatin remodeler Brg1
Molecular and Cellular Neuroscience. 2014 PMID:24561795 |
|
156. Phosphorylation of α-tubulin by protein kinase C stimulates microtubule dynamics in human breast cells
Cytoskeleton. 2014 PMID:24574051 |
|
157. SHP2 Phosphatase Promotes Mast Cell Chemotaxis toward Stem Cell Factor via Enhancing Activation of the Lyn/Vavac Signaling Axis
The Journal of Immunology. 2014 PMID:24733849 |
|
158. ROBO1. a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: Study in African-American and Caucasian prostate cancer models
International Journal of Cancer. 2014 PMID:24752651 |
|
159. Transcription factors NRF2 and nf-kb are coordinated effectors of the RHO family. GTP binding protein rac1 during inflammation
J Biol Chem. 2014 PMID:24759106 |
|
160. PI(4.5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site
Development. 2014 PMID:24821989 |
|
161. Loss of ARHGDIA expression is associated with poor prognosis in HCC and promotes invasion and metastasis of HCC cells
Int J Oncol. 2014 PMID:24859471 |
|
162. srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1
Asian Pac J Trop Med. 2014 PMID:25149377 |
|
163. Canonical and Non-canonical G-protein Signaling Helps Coordinate Actin Dynamics to Promote Macrophage Phagocytosis of Zymosan
Mol Cell Biol. 2014 PMID:25225330 |
|
164. p53 Down Regulates PDGF-Induced Formation of Circular Dorsal Ruffles in Rat Aortic Smooth Muscle Cells
PLoS One. 2014 PMID:25247424 |
|
165. TRPM2 mediates ischemic kidney injury and oxidant stress through RAC1
J Clin Invest. 2014 PMID:25295536 |
|
166. Triclosan Potentiates Epithelial-To-Mesenchymal Transition in Anoikis-Resistant Human Lung Cancer Cells
PLoS One. 2014 PMID:25329306 |
|
167. cAMP controls the restoration of endothelial barrier function after thrombin‐induced hyperpermeability via Rac1 activation
Physiological Reports. 2014 PMID:25344477 |
|
168. Cisplatin at Sub-toxic Levels Mediates Integrin Switch in Lung Cancer Cells
Anticancer Research. 2014 PMID:25503138 |
|
169. Geometry sensing through POR1 regulates Rac1 activity controlling early osteoblast differentiation in response to nanofiber diameter
Integr Biol (Camb). 2014 PMID:25539497 |
|
170. Neuregulin Mediates F-actin-driven Cell Migration through Inhibition of Protein Kinase D1 via Rac1 Protein
J Biol Chem. 2013 PMID:23148218 |
|
171. Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering beta-catenin transcriptional activity under high glucose conditions
Int J Biochem Cell Biol. 2013 PMID:23153508 |
|
172. Reactive Oxygen Species Are Induced by Kaposi’s Sarcoma-Associated Herpesvirus Early during Primary Infection of Endothelial Cells To Promote Virus Entry
J Virol. 2013 PMID:23175375 |
|
173. Essential Role of Class II Phosphatidylinositol-3-kinase-C2alpha in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells
J Biol Chem. 2013 PMID:23192342 |
|
174. PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowt
J Cell Sci. 2013 PMID:23321640 |
|
175. Deficiencies of the Lipid-Signaling Enzymes Phospholipase D1 and D2 Alter Cytoskeletal Organization. Macrophage Phagocytosis. and Cytokine-Stimulated Neutrophil Recruitment
PLoS One. 2013 PMID:23383154 |
|
176. Myocardial Rac1 exhibits partial involvement in thyroxin-induced cardiomyocyte hypertrophy and its inhibition is not sufficient to improve cardiac dysfunction or contractile abnormalities in mouse papillary muscles
J Cardiovasc Pharmacol. 2013 PMID:23429587 |
|
177. A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates
Autophagy. 2013 PMID:23439251 |
|
178. Rac1 is required for matrix metalloproteinase-13 production by chondrocytes in response to fibronectin fragments
Arthritis Rheum. 2013 PMID:23460186 |
|
179. Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization
Development. 2013 PMID:23533177 |
|
180. Fer Protein-Tyrosine Kinase Promotes Lung Adenocarcinoma Cell Invasion and Tumor Metastasis
Mol Cancer Res. 2013 PMID:23699534 |
|
181. Pilus Phase Variation Switches Gonococcal Adherence to Invasion by Caveolin-1-Dependent Host Cell Signaling
PLoS Pathog. 2013 PMID:23717204 |
|
182. ArhGAP15. a Rac-specific GTPase-activating Protein. Plays a Dual Role in Inhibiting Small GTPase Signaling
J Biol Chem. 2013 PMID:23760270 |
|
183. Kalirin-7 Mediates Cocaine-Induced AMPA Receptor and Spine Plasticity. Enabling Incentive Sensitization
J Neurosci. 2013 PMID:23825406 |
|
184. p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
PLoS One. 2013 PMID:24019894 |
|
185. Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial–mesenchymal transition of cancer cells
Cell Death Dis. 2013 PMID:24113182 |
|
186. A directional switch of integrin signaling and a new anti-thrombotic strategy
Nature. 2013 PMID:24162846 |
|
187. JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation
J Cell Biol. 2013 PMID:24368807 |
|
188. he cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling
Cell Microbiol. 2012 PMID:21999233 |
|
189. Interferon gamma induces actin polymerization. Rac1 activation and down regulates phagocytosis in human monocytic cells
Cytokine. 2012 PMID:22137120 |
|
190. Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac
Am J Pathol. 2012 PMID:22203054 |
|
191. Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions
J Cell Sci. 2012 PMID:22349701 |
|
192. rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
Nat Neurosci. 2012 PMID:22522400 |
|
193. Antagonistic activities of Rho and Rac GTPases underlie the transition from neural crest delamination to migration
Dev Dyn. 2012 PMID:22553120 |
|
194. miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling
EMBO J. 2012 PMID: 22588079 |
|
195. Interferon-beta Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
Sci Signal. 2012 PMID:22623753 |
|
196. Rac1 inhibition prevents tissue contraction and MMP mediated matrix remodeling in the conjunctiva
Invest Ophthalmol Vis Sci. 2012 PMID:22695959 |
|
197. Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
J Cell Biol. 2012 PMID:22891260 |
|
198. Rac-induced left ventricular dilation in thyroxin-treated ZmRacD transgenic mice: role of cardiomyocyte apoptosis and myocardial fibrosis
PLoS One. 2012 PMID:22936985 |
|
199. Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion
PLoS One. 2012 PMID:23185572 |
|
200. Rac1 controls Schwann cell myelination through cAMP and NF2/merlin
J Neurosci. 2012 PMID:23197717 |
|
201. Nerve growth factor-induced formation of axonal filopodia and collateral branches involves the intra-axonal synthesis of regulators of the actin-nucleating Arp2/3 complex
J Neurosci. 2012 PMID:23223289 |
|
202. Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation
Am J Physiol Heart Circ Physiol. 2011 PMID:21037229 |
|
203. K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity
PLoS One. 2011 PMID:21358804 |
|
204. Asymmetric Mbc. active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila
Development. 2011 PMID:21389053 |
|
205. Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism
ACS Nano. 2011 PMID:21563770 |
|
206. R-Ras and Rac GTPase Cross-talk Regulates Hematopoietic Progenitor Cell Migration. Homing. and Mobilization
J Biol Chem. 2011 PMID:21572048 |
|
207. Differential roles of Smad2 and Smad3 in the regulation of TGF-beta1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
Mol Cancer. 2011 PMID:21624123 |
|
208. NADPH oxidase activation by hyperglycaemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1
Cardiovasc Res. 2011 PMID:21859816 |
|
209. Latent KSHV infection increases the vascular permeability of human endothelial cells
Blood. 2011 PMID:21881052 |
|
210. Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype
J Cell Biol. 2011 PMID:21893601 |
|
211. Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I
Int J Cell Biol. 2011 PMID:21961005 |
|
212. Ethanol increases p190RhoGAP activity. leading to actin cytoskeleton rearrangements
J Neurochem. 2011 PMID:21985251 |
|
213. Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis
J Leukoc Biol. 2010 PMID:20610796 |
|
214. Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells
FEBS Lett. 2010 PMID:20621840 |
|
215. Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells
J Periodontol. 2010 PMID:20636139 |
|
216. Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome
J Neurosci. 2010 PMID:20720104 |
|
217. SUMOylation of the GTPase Rac1 is required for optimal cell migration
Nat Cell Biol. 2010 PMID:20935639 |
|
Rac Activation Assay.
MEF cells were treated with (lane 2) or without (lane 1) PDGF. Cell lysates were incubated with an anti-Rac-GTP monoclonal antibody (Cat # 26903) (top panel). Th precipitated active Rac was immunoblotted with an anti-Rac rabbit polyclonal antibody (Cat # 21003). The bottom panel shows the Western blot with anti-Rac of the cell lysates used (5% of that used in the top panel).
Immunofluorescence for the active Rac using Anti-Rac1-GTP Mouse Monoclonal Antibody [26903] on Mouse embryos at the 0- or 1-somite stages – F-actin (magenta) and GTP-Rac1 (green)
Immunofluorescence for the active Rac using Anti-Rac1-GTP Mouse Monoclonal Antibody [26903] shows Rac-GTP immunolabeling (green) in combination with cofilin (red) on brain tissue sections.
The tissue sections were fixed with -20 ºC methanol or 4% paraformaldehyde (fixation time 1 hr) and stained with antibody at 1:1000 in 0.1M Phosphate buffer with 0.3% Triton X, and 4% BSA for 24h at room temperature. Secondary antibodies were anti-mouse AlexaFluor488 and anti-rabbit AlexaFluor594 at 1:1000.
Immunofluorescence for the Rac1-GTP using Anti-Rac1-GTP Mouse Monoclonal Antibody [26903] on the polar cells of mouse embryo. Rac1-GTP staining (Red) is observed only on the apical surface of the polar cells
