NewEast Biosciences
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Phone:   610-945-2007      Fax:   610-945-2008
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Peer Reviews
Publications
Activation Assay Kits
Arf6 Cdc42 13
i o s
z Rab11 Rab3
Rab35 Rab4A Rab5
Rab7 Rab5A Rab5B
Rab5C Rac1 Ran
Rap1 RalA RalB
Ras RheB RhoA
Sar1
Antibodies for GTP-bound G Proteins
Arf6 Cdc42 13
i o s
z Rab11 Rab3
Rab35 Rab4A Rab5
Rab7 Ran Rac1
Ral Rap1 Ras
RheB RhoA Sar1
cAMP/cGMP EIA Kits
without Acetylation
cAMP cGMP
Biomarkers
β-Actin β-Tubulin Albumin
Apo A1 cAMP cGMP
CystatinC Fascin GAPDH
Kim-1 MUC1 Orai1-L1
Orai1-L2 PIK3CA(E545K) Septin9
TFF3 Transferrin Vimentin
β1-Adrenergic receptor
Apo A1 EIA Kit
Fascin EIA Kit
Cystatin C ELISA Kit
Monoclonal Antibodies
Arf1 Arf6 Arl1
Arl3 Cdc42 12
13 14 i
o q s
z Rab5 Rab11
Rac1 Rac3 Ran
Ral RalB Ras
RheB RhoA Sar1
Protocols
Protocol for IF/IHC
   
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Phone:  610-945-2007
Fax     :  610-945-2008
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Publications:

IHC/IF Applications
1.  K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity
     OPLoS ONE, 2011 - dx.plos.org
2.  Antioxidants Counteract Nicotine and Promote Migration via RacGTP in Oral Fibroblast Cells
     Journal of Periodontology, 2010
3.  Physiological Activation of Synaptic Rac> PAK (p-21 Activated Kinase) Signaling Is Defective in a Mouse Model of Fragile X Syndrome
     The Journal of Neuroscience, 2010
4.  Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization
     J. Biol. Chem. 2011
IP Applications
1.  β-arrestin but not G protein-mediated signaling by the “decoy” receptor CXCR7
     PNAS, 2009
2.  Polarized Migration of Lymphatic Endothelial Cells is Critically Dependent on Podoplanin Regulation of Cdc42
     Am J Physiol Lung Cell Mol Physiol, 2010
3.  SUMOylation of the GTPase Rac1 is required for optimal cell migration
     Nature Cell Biology, 2010
4.  WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins
     Cellular Signalling, 2010
5.  Na/H Exchanger Regulatory Factors Control Parathyroid Hormone Receptor Signaling by Facilitating Differential Activation of Ga Protein Subunits
     J. Biol. Chem., 2010
6.  Na/H exchanger regulatory factors control PTH receptor signaling by facilitating differential activation of Gα protein subunits
     Journal of Biological Chemistry, 2010
7.  Multiple mechanisms of NADPH oxidase inhibition by type A and type B Francisella tularensis
     Journal of Leukocyte Biology, 2010
8.  12/13 inhibition enhances the anti-cancer effect of bortezomib through PSMB5 downregulation
     Carcinogenesis, 2010
9.  Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
     Molecular Cancer, 2011
10.  Aspect Ratio Determines the Quantity of Mesoporous Silica Nanoparticle Uptake by a Small GTPase-Dependent Macropinocytosis Mechanism
11.  NADPH oxidase activation by hyperglycemia in cardiomyocytes is independent of glucose metabolism but requires SGLT1
Cardiovascular Research, 2011
12.  The Aarskog-Scott syndrome protein Fgd1 regulates podosome formation and extracellular matrix remodeling in TGF {beta}-stimulated aortic endothelial cells
    T Daubon, R Buccione and E Genot     Molecular and Cellular Biology, 2011
13.  Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype
     Journal of Cell Biology, 2011
14.  Latent KSHV infection increases the vascular permeability of human endothelial cells
    Blood, 2011
15.  Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I
    International Journal of Cell Biology, 2011
16.  CXCR4 activation defines a new subgroup of Sonic Hedgehog driven Medulloblastoma
    Cancer Research, 2011
17.  The Aarskog-Scott Syndrome Protein Fgd1 Regulates Podosome Formation and Extracellular Matrix Remodeling in Transforming Growth Factor β-Stimulated Aortic Endothelial Cells
    Molecular and Cellular Biology - 2011
18.  R-Ras and Rac GTPase Cross-talk Regulates Hematopoietic Progenitor Cell Migration, Homing, and Mobilization
    J. Biol. Chem. - 2011
19.  The cooperative action of bacterial fibronectin-binding proteins and secreted proteins promote maximal Campylobacter jejuni invasion of host cells by stimulating membrane ruffling
    Cellular Microbiology - 2011
cAMP/cGMP EIA Kits
1.  Stimulation of guanylyl cyclase-D by bicarbonate
     Biochemistry, 2009
2.  Role of Sulfhydryl-Dependent Dimerization of Soluble Guanylyl Cyclase In Relaxation of Porcine Coronary Artery to Nitric Oxide
     Oxford Journals-Cardiovascular Research, 2011
3.  Molecular analysis, developmental function and heavy metal-induced expression of ABCC5 in zebrafish
     Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2010
4.  Feedback Control Through cGMP-Dependent Protein Kinase Contributes to Differential Regulation and Compartmentation of cGMP in Rat Cardiac Myocytes
Circulation Research, 2010
Others
1.  Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells
        FEBS Letters, 2010
2.  Suppression of Tumor Angiogenesis by Gα13 Haploinsufficiency
    J. Biol. Chem., 2009
3.  Orai1 and STIM1 are critical for breast tumor cell migration and metastasis
    Cancer cell, 2009
4.  Up-regulation of Orai1 in murine allergic rhinitis
     Histochemistry and Cell Biology, 2010
5.  Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Ga13 and β-arrestin-2
     British Journal of Pharmacology, 2010
6.  Phosphorylation of VE-cadherin controls endothelial phenotypes via p120-catenin coupling and Rac1 activation
     Am J Physiol Heart Circ Physiol, 2010
7.  Heterotrimeric Gai proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis
     Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2011
8.  Some cationic porphyrins: synthesis, stabilization of G-quadruplexes, and down-regulation of c-myc in Hep G2 cells
     World Scientific, 2011
9.  2-Aminoethoxydiphenyl borate administration into the nostril alleviates murine allergic rhinitis
     American Journal of Otolaryngology - 2010
10.  SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses
     J. Biol. Chem., - 2011
11.  SUMOylation-regulated Protein Phosphorylation, Evidence from Quantitative Phosphoproteomics Analyses
     The Journal of Neuroscience - 2011