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Antibodies for GTP-bound G Proteins

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Anti Rab7-GTP Mouse Monoclonal Antibody

Price$495.00
BrandNewEastBio   
Place of OriginUSA
Catalog Number26923
ImmunogenMouse
Size30 μl
Technical InformationView technical data
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  • Summary

    Active Rab7-GTP [26923]
    [30 µL]


    Catalog Number:  26923
    Gene Symbol:  RAB7
    Description:   Anti Active Rab7 Mouse Monoclonal Antibody
    Background:   Rab7 belongs to the Rab family of small GTPases. Rab7 is located in the late endosome, lysosome, cytoplasmic vesicle, phagosome and melanosome. It is involved in the late endocytic transport and contributes to the maturation of phagosomes.
    Immunogen:   Recombinant full length protein of active Rab7
    Applications:   IP, IHC, IF
    Recommended Dilutions:   
    1 µg for ~2 mg total cellular proteins for IP 
    1:100 dilution for IHC, IF
    Concentration:   1 mg/ml
    Host:   mouse
    Format:   Liquid
    Clonality:   Monoclonal
    Isotype:   IgG
    Purity:   Purified from ascites
    Storage buffer:
    Preservative:  no
    Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
    Species Reactivity:  Anti-active Rab7 antibody recognizes active Rab7 proteins of vertebrates.
    Storage Conditions:  Store at -20°C. Avoid freeze / thaw cycles
    Download Datasheet:  
    Immunoprecipitation/Western blot:  

    Rab7 activation assay. Purified full-length Rab7 proteins were immunoprecipitated after treated with GDP (lane 1) orGTPγS (lane 2). Immunoprecipitation was done with the anti-active Rab7 monoclonal antibody (Cat. No. 26923). Immunoblot was with an anti-Rab7 polyclonal antibody (Cat. No. 2

    1069).



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    Publications:
    1.  VASP promotes TGF-β activation of hepatic stellate cells by regulating Rab11 dependent plasma membrane targeting of TGF-β receptors
        Hepatology Volume 61, Issue 1, pages 361–374, January 2015
    2.  Rab5 Activity Regulates GLUT4 Sorting into Insulin-Responsive and Non-Insulin-Responsive Endosomal Compartments: A Potential Mechanism for Development of Insulin Resistance
        Endocrinology. 2014 Sep;155(9):3315-28